The space selectivity of the hadrontherapy asks for a new approach to the delivered dose monitoring. The uncertainty on the position of the dose released in hadrontherapy is of the order of few millimeters that can be larger than the dimension of the peak of the dose release (Bragg Peak). A precise monitoring of the dose is then essential for a good quality control of the treatment. Furthermore, the dose monitoring would be particularly useful if provided during the treatment (in-beam monitoring) in order to provide a fast feedback to the beam.
It has been demonstrated that the longitudinal distribution of the emission point of charged secondaries can be correlated with the Bragg Peak position. Within the INSIDE (INnovative Solutions for In-beam DosimEtry in hadron therapy) project a new device has been designed and built to measure with high efficiency the charge particle (proton dominated) emission profile in carbon treatments.
The detector (schematized in the figure) is composed of 8 planes (in orange) of two orthogonally placed scintillating fibers layer (384 fibers each) to provide bi-dimentional view. The fibers readout is performed by means of Silicon Photomultipliers (SiPM) coupled to the the fibers on both the sides.
Useful documents:
- Thesis from M. De Simoni (pdf)
- Thesis from F. Galante (pdf-Presentation)
- Thesis from B. Di Lullo (pdf-Presentation)
- Review article from Physica Medica
Who:
G. Battistoni, M. De Simoni, M. Fischetti, M. Marafini, I. Mattei, S. Muraro, V. Patera, A. Sarti, A. Schiavi, A. Sciubba, G. Traini.
INSIDE collaboration: Dose Profiler papers
2020
- M. Fischetti et al, Inter-fractional monitoring of 12 C ions treatments: results from a clinical trial at the CNAO facility
(2020) Scientific Reports, 10.
2019
- G. Traini, et al Review and performance of the Dose Profiler, a particle therapy treatments online monitor (link to Physica Medica)
- A. Rucinksi et al, Secondary radiation measurements for particle therapy applications: Charged secondaries produced by 16O ion beams in a PMMA target at large angles (2019) Physica Medica, 64
2018
- Mirabelli, R., et al In-room performance evaluation of a novel online charged secondary particles monitor of light ions PT treatments (2018) 2018 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2018 - Proceedings
- De Simoni, et al., In-room test results at CNAO of an innovative PT treatments online monitor (Dose Profiler)(2018) Nuovo Cimento della Societa Italiana di Fisica C, 41 (6)
- Ferrero, V., et al Online proton therapy monitoring: Clinical test of a Silicon-photodetector-based in-beam PET (2018) Scientific Reports, 8
- A. Rucinski et al, Secondary radiation measurements for particle therapy applications: charged particles produced by 4He and 12C ion beams in a PMMA target at large angle 2017 Phys. Med. Biol. 63 055018
- I. Mattei et al, Charged particles and neutron trackers: Applications to particle therapy, Nuclear Instruments and Methods in Physics Research A
- I. Mattei et al, Scintillating fiber devices for particle therapy applications, IEEE ( Volume: 65 , Issue: 8 , Aug. 2018 pp 2054 - 2060)
2017
- G. Traini et al, Design of a new tracking device for on-line beam range monitor in carbon therapy Physica Medica 34 (2017) 18–27
2016
- G. Battistoni et al, Design of a tracking device for on-line dose monitoring in hadrontherapy Nuclear Instruments and Methods in Physics Research A 845 (2017) 679–683
- S. Muraro et al, Monitoring of Hadrontherapy Treatments by Means of Charged Particle Detection Front. Oncol. 6:177.
- A. Rucinski et al, Innovative Tracking Detector for Dose Monitoring in Hadron Therapy: Realization and Monte Carlo Simulations Med. Phys. 43 (6), June 2016
Collaborations:
• Fluka group in Milano and CERN
• GSI
• HIT
• Politecnico di Milano
• Univ. di Pisa
INSIDE: INnovative Solutions for In-beam DosimEtry in hadrontherapy
The INSIDE (Innovative Solutions for In-Beam Dosimetry in hadrontherapy) MIUR project is born from the collaboration of a number of Italian Universities and INFN to build a multimodal in-beam dose monitoring system able to detect at the same time, back-to-back gammas from β + annihilation and charged secondary particles with kinetic energy higher than 30 MeV. The monitor is made up of 2 planar of 10 × 20 cm2 PET heads for back-to-back gammas detection and of a 20×20 cm2 dose profiler for protons detection.
INSIDE started the first clinical trial in July 2019 to study the sensitivity of the two detectors for an inter-fractional monitoring. It is currently taking data from patients during real treatments as it is possible to see in the picture.
Who:
G. Battistoni, F. Collamati, E. De Lucia, P.M. Frallicciardi, R. Faccini, M. Marafini, S. Muraro, I. Mattei, V. Patera, L. Piersanti, A. Sarti, A. Sciubba, G. Traini, C. Voena
Collaborations:
• Fluka group in Milano and CERN
• GSI
• HIT
• Politecnico di Milano
• Univ. di Pisa
Publications from the INSIDE collaboration: Fragmentation measurements
2017
- I. Mattei et al, Addendum: Measurement of charged particle yields from PMMA irradiated by a 220 MeV/u 12C beam 2017 Phys. Med. Biol. 62 8483
- M. Marafini et al, Secondary radiation measurements for particle therapy applications: nuclear fragmentation produced by 4He ion beams in a PMMA target 2017 Phys. Med. Biol. 62 1291
- I. Mattei et al, Secondary radiation measurements for particle therapy applications: prompt photons produced by 4He, 12C and 16O ion beams in a PMMA target 2017 Phys. Med. Biol. 62 1438
- M.Vanstalle et al, Benchmarking Geant4 hadronic models for prompt-γ monitoring in carbon ion therapy Med. Phys. 44 (8), August 2017
2016
- A. Rucinski et al, Secondary Radiation Measurements for Charged Particle Therapy Monitoring: Fragmentation of Therapeutic He, C and O Ion Beams Impinging On a PMMA Target Med. Phys. 43 (6), June 2016
- M.Toppi et al, Measurement of secondary particle production induced by particle therapy ion beams impinging on a PMMA target EPJ Web of Conferences 117, 05007 (2016)
2015
- I. Mattei at al, Prompt-γ production of 220 MeV/u 12C ions interacting with a PMMA target 2015 JINST 10 P10034
- G. Battistoni et al, Measurement of charged particle yields from therapeutic beams in view of the design of an innovative hadrontherapy dose monitor 2015 JINST 10 C02032
- A. Rucinski et al, Measurements of secondary particles emitted by 12C, 4He and 16O ion beams in view of innovative dose profiling technique in Particle Therapy 14th International Conference on Nuclear Reaction Mechanisms, Villa Monastero, Varenna, Italy, 15 - 19 Jun 2015, pp.355
- M. Marafini et al, The INSIDE Project: Innovative Solutions for In-Beam Dosimetry in Hadrontherapy ACTA PHYSICA POLONICA A Vol. 127 (2015)
- F. Pennazio et al, A Study of Monitoring Performances with the INSIDE System ACTA PHYSICA POLONICA A Vol. 127 (2015)
- Riccardo Faccini & Vincenzo Patera, REVIEW: Dose monitoring in particle therapy Mod. Phys. Lett. A 30, 1540023 (2015)
2014
- L.Piersanti et al, Measurement of charged particle yields from PMMA irradiated by a 220 MeV/u 12C beam 2014 Phys. Med. Biol. 59 1857
- C.Agodi et al, Corrigendum:Charged particle’s flux measurement from PMMA irradiated by 80 MeV/u carbon ion beam Phys. Med. Biol. 59 7563
2013
- F. Bellini et al, Extended calibration range for prompt photon emission in ion beam irradiation Nuclear Instruments and Methods in Physics Research A 745 (2014) 114–118
2012
- C.Agodi et al, Charged particle’s flux measurement from PMMA irradiated by 80 MeV/u carbon ion beam Phys. Med. Biol. 57 5667
- C.Agodi et al, Study of the time, space distribution of β+ emitters from 80 MeV/u carbon ion beam irradiation on PMMA Nuclear Instruments and Methods in Physics Research B 283 (2012) 1–8
- C.Agodi et al, Precise measurement of prompt photon emission from 80 MeV/u carbon ion beam irradiation 2012 JINST 7 P03001
- S. Fiore et al, Neutral and Charged Particles' Flux Measurement for Released Dose Imaging in Hadrontherapy IEEE Nuclear Science Symposium Conference Record, pp. 1275-1278, 2012.
2011
- C.Agodi et al, Measurement of prompt photons, gamma PET from 80 MeV/u carbon beam on PMMA target, IEEE Nuclear Science Symposium Conference Record, pp. 3522-3528, 2011.